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oai:open-archive.highwire.org:ageing:21/2/1032015-05-19HighWireOUPageing:21:2
C-Peptide Response to Oral Glucose and its Clinical Role in Elderly People
WICKRAMASINGHE, L. S. P.
CHAZAN, B. I.
FARROW, M.
BANSAL, S. K.
BASU, S. K.
Articles
C-Peptide response to oral glucose was measured in 45 elderly diabetics, in whom final treatment was established on clinical grounds during a 16–18 months follow-up. The diabetic patients comprised 19 ultimately classified as insulin-dependent (IDD) (group 1) and 26 regarded as non-insulin-dependent (NIDD) (group 2). Fifteen matched controls (group 3) and 15 young controls (group 4) were similarly studied. Fasting C-peptide values were lower in groups 1 and 2(1.48±0.39 and 2.14±0.22 ng/ml; mean±SEM, respectively) compared with groups 3 and 4 (2.51±0.16 and 2.71±0.20 ng/ml, respectively) (p<0.001). Peak C-peptide levels were reached at 30 min in healthy young and at 60 min in healthy elderly. All non-diabetic control subjects showed a peak of at least 6.5 ng/ml and an increment of at least 4 ng/ml. The ratio of C-peptide increment/blood glucose increment (100 ΔCP/ΔBG) at 60 min derived to assess β-cell function was at least 90 in all healthy subjects. The ratio was less than 10 in 68% of IDD but in only 27% of NIDD patients (p<0.01). The 100ΔCP/ΔBG was inversely related to the prevailing fasting blood glucose (FBG) (p<0.001). These findings suggest that C-peptide response to oral glucose may be a useful test in certain elderly diabetic patients whose insulin dependence is in question.
Oxford University Press
1992-03-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/21/2/103
http://dx.doi.org/10.1093/ageing/21.2.103
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/1092015-05-19HighWireOUPageing:21:2
Perceived Health in Hip-fracture Patients: A Prospective Follow-up of 100 Patients
BORGQUIST, LARS
NILSSON, LARS T.
LINDELÖW, GÖRAN
WIKLUND, INGELA
THORNGREN, KARL-GÖRAN
Articles
We report the impact of the treatment and rehabilitation in hip-fracture patients by using self-assessment instruments of perceived health and relate them to objective outcome assessments, such as ADL (personal hygiene/dressing), walking ability and technical complications. Subjective and objective status for 100 hip-fracture patients admitted from their own home, and rehabilitated in primary health care, were registered over 1 year after fracture. Mean age was 74, and 80% of the patients were women. Two self-assessment questionnaires: the Nottingham Health Profile (NHP part 1) and the Mood Adjective Checklist (MACL) were answered by the patients 6 and 12 months after fracture and compared with functional status (ADL, and walking ability) 4 months after fracture. Problems related to the hip fracture such as pain and physical mobility had most effect on the self-assessment questionnaire (NHP) and were in accordance with the district physiotherapists' evaluation of function. Patients with complications (resulting in nail extraction and total hip replacement) after the primary hip osteosynthesis and patients with a poor function 4 months after fracture had scores in the self-assessment questionnaires indicating a more pronounced and distressing impact of the disease. Small changes in subjective mood (MACL) were found. In an acute, curable, disease such as hip fracture the objective outcome seems as informative as the subjective evaluations of patients' self-assessment.
Oxford University Press
1992-03-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/21/2/109
http://dx.doi.org/10.1093/ageing/21.2.109
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/1172015-05-19HighWireOUPageing:21:2
Post-menopausal Atrophy in Elderly Women: Is a Vaginal Smear Necessary for Diagnosis?
CAPEWELL, ANN. E.
McINTYRE, MARGARET A.
ELTON, ROBERT A.
Articles
The diagnosis of post-menopausal atrophy should preferably be confirmed before any trial of oestrogen treatment for genito-urinary symptoms. The ideal method, cytological analysis of a vaginal wall smear, is not always feasible in elderly women. Might physical examination alone be sufficient? This study aimed to determine which clinical features might best predict atrophy on the smear. Of 120 consecutive women admitted to an acute geriatric unit (mean age 82 years), satisfactory smears were obtainable from 70 (58%). Sixty per cent of these showed severe atrophy but almost one-fifth showed no atrophic changes. Degree of atrophy correlated with physical thinness (p<0.01), low parity (p<0.01) and dryness on vaginal examination (p<0.001). However, none of the other physical findings traditionally thought to indicate atrophy were found to be associated, nor were age or medication. In contrast, severe atrophy was present in only one of nine women with breast cancer (p<0.01). This merits further study.
Oxford University Press
1992-03-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/21/2/117
http://dx.doi.org/10.1093/ageing/21.2.117
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/1212015-05-19HighWireOUPageing:21:2
Sleep Disordered Breathing and Cognitive Function in a Retirement Village Population
HAYWARD, LINDA
MANT, ANDREA
EYLAND, ANN
HEWITT, HELEN
PURCELL, CATHERINE
TURNER, JANE
GOODE, ELIZABETH
COUNT, ANN LE
POND, DIMITY
SAUNDERS, NICHOLAS
Articles
Sleep disordered breathing (SDB) may be associated with cognitive dysfunction in non-demented elderly people. A random sample of 96 retirement village residents were given both neuropsychological assessment and overnight sleep monitoring with a portable microprocessor based system (Vitalog PMS-8). Respiratory disturbance index (RDI) was calculated as the number of apnoeas and hypopnoeas per hour of sleep. RDI was not associated with ‘memory’, ‘verbal’, and ‘motor’ factors identified from the analysis of cognitive tests, but was associated with the ‘cerebral efficiency’ factor (R2=0.21, p<0.0001). Seventy-three subjects had repeat neuropsychological tests, median time to follow-up being 17 months. Baseline RDI did not predict changes in scores on the two factors identified from the second analysis. We conclude that mild to moderate disturbance of breathing during sleep is not associated with cognitive dysfunction in non-demented subjects.
Oxford University Press
1992-03-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/21/2/121
http://dx.doi.org/10.1093/ageing/21.2.121
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/1292015-05-19HighWireOUPageing:21:2
A Longitudinal Genetic Study of Tail Tendon Fibre Break Time
HELLER, DEBRA A.
McCLEARN, GERALD E.
Articles
Tail tendon fibre break time (TTFBT), an indicator of collagen cross-linkage, was measured longitudinally in C57BL/6, DBA/2 and B6D2F1 mice, and F2 and backcross genotypes. TTFBT was assessed at 50, 150, 300 and 450 days of age. The distribution of means of these six genotypes suggests substantial genetic influence on this phenotype. Broad sense heritability, as assessed in a classical biometrical analysis, was negligible at 50 and 150 days, but accounted for between 25 and 43% of the variance at 300 to 450 days. The stability and reliability of TTFBT were also examined. Reliability was extremely high for each occasion; stability increased from moderate to substantial levels with increasing age, and may be influenced by heterozygosity.
Oxford University Press
1992-03-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/21/2/129
http://dx.doi.org/10.1093/ageing/21.2.129
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/1352015-05-19HighWireOUPageing:21:2
Disability and the Diagnostic Quality of Barium Meals in Elderly Patients
SANGSTER, GRAEME
WILLIAMS, CHARLES E.
GARVEY, CONALL J.
BALDWIN, R. NEIL
Articles
It is often assumed that the diagnostic quality of a barium meal is likely to be impaired in elderly or disabled patients. We related the technical and diagnostic quality of 76 consecutive barium meals to the physical and mental status of the elderly patients undergoing the investigation. Fifty-three (70%) of the examinations were of good or excellent diagnostic quality and we found no association between diagnostic quality of the barium meal and the patient's age, mobility score, activities of daily living score or mental test score.
Oxford University Press
1992-03-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/21/2/135
http://dx.doi.org/10.1093/ageing/21.2.135
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/1392015-05-19HighWireOUPageing:21:2
Pathogenesis of Vertebral Crush Fractures in Men
BAILLIE, S. P.
DAVISON, C. E.
JOHNSON, F. J.
FRANCIS, R. M.
Articles
In a series of 70 men with vertebral crush fractures, 38 (54%) were found to have an underlying secondary cause of osteoporosis such as hypogonadism (16%), oral steroid therapy (13%), neoplastic disease (9%), excess alcohol consumption (6%), gastric surgery (1%) or a combination of these factors (10%). The diagnosis of secondary osteoporosis was not always apparent from the clinical history and physical examination, suggesting that appropriate investigations should be performed in all men with vertebral crush fractures.
Oxford University Press
1992-03-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/21/2/139
http://dx.doi.org/10.1093/ageing/21.2.139
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/1422015-05-19HighWireOUPageing:21:2
Review: Audit Measures: Quality of Life Instruments for Everyday Use with Elderly Patients
FLETCHER, ASTRID E.
DICKINSON, EDWARD J.
PHILP, IAN
Review
Oxford University Press
1992-03-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/21/2/142
http://dx.doi.org/10.1093/ageing/21.2.142
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/151-a2015-05-19HighWireOUPageing:21:2
Book Reviews
WINNER, SIMON
Book Reviews
Oxford University Press
1992-03-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/21/2/151-a
http://dx.doi.org/10.1093/ageing/21.2.151-a
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/151-b2015-05-19HighWireOUPageing:21:2
Book Reviews
WALKER, ALAN
Book Reviews
Oxford University Press
1992-03-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/21/2/151-b
http://dx.doi.org/10.1093/ageing/21.2.151-b
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/1512015-05-19HighWireOUPageing:21:2
Book Reviews
POST, FELIX
Book Reviews
Oxford University Press
1992-03-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/21/2/151
http://dx.doi.org/10.1093/ageing/21.2.151
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/152-a2015-05-19HighWireOUPageing:21:2
Book Reviews
POLLITT, PENELOPE
Book Reviews
Oxford University Press
1992-03-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/21/2/152-a
http://dx.doi.org/10.1093/ageing/21.2.152-a
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/1522015-05-19HighWireOUPageing:21:2
Book Reviews
GILHOOLY, MARY L. M.
Book Reviews
Oxford University Press
1992-03-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/21/2/152
http://dx.doi.org/10.1093/ageing/21.2.152
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/153-a2015-05-19HighWireOUPageing:21:2
Book Reviews
HAGGARD, MARK
Book Reviews
Oxford University Press
1992-03-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/21/2/153-a
http://dx.doi.org/10.1093/ageing/21.2.153-a
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/153-b2015-05-19HighWireOUPageing:21:2
Book Reviews
PHILLIPSON, CHRIS
Book Reviews
Oxford University Press
1992-03-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/21/2/153-b
http://dx.doi.org/10.1093/ageing/21.2.153-b
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/1532015-05-19HighWireOUPageing:21:2
Book Reviews
DAVIES, IOAN
Book Reviews
Oxford University Press
1992-03-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/21/2/153
http://dx.doi.org/10.1093/ageing/21.2.153
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/154-a2015-05-19HighWireOUPageing:21:2
Book Reviews
ARIE, TOM
Book Reviews
Oxford University Press
1992-03-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/21/2/154-a
http://dx.doi.org/10.1093/ageing/21.2.154-a
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/1542015-05-19HighWireOUPageing:21:2
Book Reviews
UNWIN, MONICA
Book Reviews
Oxford University Press
1992-03-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/21/2/154
http://dx.doi.org/10.1093/ageing/21.2.154
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/155-a2015-05-19HighWireOUPageing:21:2
Book Reviews
CASTLEDEN, MARK
Book Reviews
Oxford University Press
1992-03-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/21/2/155-a
http://dx.doi.org/10.1093/ageing/21.2.155-a
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/155-b2015-05-19HighWireOUPageing:21:2
Book Reviews
FRASER, MORRIS
Book Reviews
Oxford University Press
1992-03-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/21/2/155-b
http://dx.doi.org/10.1093/ageing/21.2.155-b
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/1552015-05-19HighWireOUPageing:21:2
Book Reviews
WILCOCK, G. K.
Book Reviews
Oxford University Press
1992-03-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/21/2/155
http://dx.doi.org/10.1093/ageing/21.2.155
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/1562015-05-19HighWireOUPageing:21:2
Books Received
Books Received
Oxford University Press
1992-03-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/21/2/156
http://dx.doi.org/10.1093/ageing/21.2.156
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/772015-05-19HighWireOUPageing:21:2
From Plaque to Placement; a Model for Alzheimer's Disease
EVANS, J. GRIMLEY
Commentary
Oxford University Press
1992-03-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/21/2/77
http://dx.doi.org/10.1093/ageing/21.2.77
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/812015-05-19HighWireOUPageing:21:2
Gastrointestinal Absorption of Aluminium in Alzheimer's Disease: Response to Aluminium Citrate
TAYLOR, GEOFFREY A.
FERRIER, I. NICOL
McLOUGHLIN, IAN J.
FAIRBAIRN, ANDREW F.
McKEITH, IAN G.
LETT, DEBRA
EDWARDSON, JAMES A.
Articles
Alzheimer's disease (AD) has been linked to genetic defects on chromosome 21 in some families, but most elderly cases appear to be sporadic and may, at least in part, involve environmental risk factors. Several lines of evidence suggest that aluminium may be involved in the aetiology of AD. However, despite universal exposure to aluminium in the diet, only some people develop the disease. We have developed a test of aluminium absorption using an aluminium citrate drink, to examine the hypothesis that sufferers from AD show increased aluminium absorption. In a younger group of AD patients aluminium absorption was significantly raised compared with age-matched controls. Aluminium absorption increased with age in the control group but was not significantly raised in older AD patients when compared with age-matched controls.
Oxford University Press
1992-03-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/21/2/81
http://dx.doi.org/10.1093/ageing/21.2.81
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/912015-05-19HighWireOUPageing:21:2
Plasma Concentrations of Vitamins A and E and Carotenoids in Alzheimer's Disease
ZAMAN, Z.
ROCHE, S.
FIELDEN, P.
FROST, P. G.
NIRIELLA, D. C.
CAYLEY, A. C. D.
Articles
In a case/control study, serum concentrations of vitamins A and E and major carotenoids were determined in patients with Alzheimer's disease, multi-infarct dementia and control subjects. The results showed that both Alzheimer's and multi-infarct dementia patients had significantly lower levels of vitamin E and β-carotene than controls (vitamin E: 18.65±3.62 μmol/l in Alzheimer's disease and 15.80±6.93 μmol/l in multi-infarct dementia versus 30.03±12.03 μmol/l in controls; β-carotene <0.13 to 0.42 μmol/l in Alzheimer's disease and <0.13 to 0.30 μmol/l in multi-infarct dementia versus 0.13 to 1.53 μmol/l in controls). Vitamin A was significantly reduced only in the Alzheimer's patients (1.56±0.78 μmol/l in Alzheimer's disease versus 2.13±0.86 μmol/l in controls).
Oxford University Press
1992-03-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/21/2/91
http://dx.doi.org/10.1093/ageing/21.2.91
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/952015-05-19HighWireOUPageing:21:2
The Influence of Age on Policies for Admission and Thrombolysis in Coronary Care Units in the United Kingdom
DUDLEY, N. J.
BURNS, E.
Articles
Age is an important factor influencing survival following an acute myocardial infarction. In clinical practice many elderly patients are neither admitted to coronary care nor receive thrombolytic therapy. A postal questionnaire was sent to all 175 consultants in charge of coronary care units in the United Kingdom to determine whether age-related policies are being operated which are limiting the access of elderly patients to life-saving interventions. One hundred and thirty-four questionnaires (77%) were returned. One-fifth of coronary care units operate an age-related admission policy, and two-fifths operate an age-related thrombolysis policy. The age limits used by many of these units are likely to exclude large numbers of patients who could benefit from cardiac monitoring and resuscitation as well as thrombolytic treatment. The abolition of age-related policies would help to ensure that thrombolysis is readily available to the group of patients most likely to benefit from it.
Oxford University Press
1992-03-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/21/2/95
http://dx.doi.org/10.1093/ageing/21.2.95
en
Copyright (C) 1992, British Geriatrics Society
oai:open-archive.highwire.org:ageing:21/2/992015-05-19HighWireOUPageing:21:2
Circadian Variation in the Frequency of Onset of Chest Pain in Elderly Patients with Acute Myocardial Infarction
THOMPSON, DAVID R.
POHL, JURGEN E. F.
SUTTON, TERENCE W.
Articles
This study reports the time of onset of chest pain in 792 consecutive elderly patients admitted to a coronary care unit with myocardial infarction during a 10-year period. Statistical analysis demonstrated a bimodal frequency distribution with peaks in the time of Onset of chest pain between 23 h 30 and 00 h 30 and between 06 h 30 and 08 h 30.
Oxford University Press
1992-03-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/21/2/99
http://dx.doi.org/10.1093/ageing/21.2.99
en
Copyright (C) 1992, British Geriatrics Society