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oai:open-archive.highwire.org:ageing:3/2/1062015-05-19HighWireOUPageing:3:2
STUDIES IN SERUM DIGOXIN
ROE, P. F.
ABBOTT, A. L.
Articles
Using a standardized assay technique, serum digoxin has been estimated in a number of elderly patients. The precision possible with this technique is acceptable with higher, potentially toxic serumdigoxin levels but less so at lower levels. Standard conditions were virtually impossible to obtain in view of the many pathological and biochemical abnormalities so often present in the elderly A series of simple measurements was made to determine:<l type="letter"><li> the variation of serum digoxin between individuals receiving the same dose of oral digoxin, and in the same individuals at different times and </li><li> the toxic and non-toxic ranges of serum digoxin. </li></l> The overlap between toxic and non-toxic ranges was found to be considerably greater than previously reported in younger patients. A simple formula is suggested for the determination of the overall state of digitalisation in a given patient. It is concluded that for elderly patients in clinical situations, the estimation of serum digoxin is of definite value, but less certainly so than for younger subjects.
Oxford University Press
1974-05-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/3/2/106
http://dx.doi.org/10.1093/ageing/3.2.106
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/1132015-05-19HighWireOUPageing:3:2
THE RELEVANCE OF AMERICAN LIFE SATISFACTION INDICES FOR RESEARCH ON BRITISH SUBJECTS BEFORE AND AFTER RETIREMENT
BIGOT, A.
Articles
A Life Satisfaction Index was administered to 150 manual and professional workers, aged 55–79 and scores were also computed for a shorter derived Life Satisfaction Index. The analysis dealt with the association between index items, the feasibility of shortened indices, the responses of the subjects on the indices and the relationship between the indices, age, and socio-economic status. Results indicated that certain index items were irrelevant, and associations between items were different from those obtained in previous studies. Two components of life satisfaction emerged, namely ‘Acceptance-Contentment’ and ‘Achievement-Fulfilment’. The components or indices used separately proved to be differentially sensitive to age and socio-econornic status before and after retirement.
Oxford University Press
1974-05-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/3/2/113
http://dx.doi.org/10.1093/ageing/3.2.113
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/1222015-05-19HighWireOUPageing:3:2
FURTHER STUDIES OF THYROID FUNCTION TESTS IN THE ELDERLY AT HOME
TAYLOR, B. B.
THOMSON, J. A.
CAIRD, F. I.
Articles
The serum PB127I, T<inf>3</inf> resin uptake, and thyroxine (T<inf>4</inf>) concentration were measured and the ‘free thyroxine’ and ‘free Thyopac’ indices calculated in 97 people aged 70 or more living at home. PB127I was below 4 μg/100 ml in eight subjects, of whom four were shown by the other tests to be hypothyroid. A drug history indicated the likely cause of a PB127I of over 8.5 μg/100 ml in three of nine subjects, all of whom were shown to have normal thyroid function by the other tests. No relation was demonstrable between PB127I and serum albumin concentration. The value of these tests as part of a screening programme for the elderly is discussed.
Oxford University Press
1974-05-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/3/2/122
http://dx.doi.org/10.1093/ageing/3.2.122
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/1272015-05-19HighWireOUPageing:3:2
SPECIAL COURSE AT LEEDS UNIVERSITY
Articles
Oxford University Press
1974-05-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/3/2/127
http://dx.doi.org/10.1093/ageing/3.2.127
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/128-a2015-05-19HighWireOUPageing:3:2
BOOK REVIEWS
POST, FELIX
Book Reviews
Oxford University Press
1974-05-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/3/2/128-a
http://dx.doi.org/10.1093/ageing/3.2.128-a
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/1282015-05-19HighWireOUPageing:3:2
BOOK REVIEWS
AMULREE,
Book Reviews
Oxford University Press
1974-05-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/3/2/128
http://dx.doi.org/10.1093/ageing/3.2.128
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/129-a2015-05-19HighWireOUPageing:3:2
BOOK REVIEWS
HALL, D. A.
Book Reviews
Oxford University Press
1974-05-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/3/2/129-a
http://dx.doi.org/10.1093/ageing/3.2.129-a
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/1292015-05-19HighWireOUPageing:3:2
BOOK REVIEWS
ISAACS, BERNARD
Book Reviews
Oxford University Press
1974-05-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/3/2/129
http://dx.doi.org/10.1093/ageing/3.2.129
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/130-a2015-05-19HighWireOUPageing:3:2
BOOK REVIEWS
WEDGWOOD, J.
Book Reviews
Oxford University Press
1974-05-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/3/2/130-a
http://dx.doi.org/10.1093/ageing/3.2.130-a
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/130-b2015-05-19HighWireOUPageing:3:2
BOOK REVIEWS
RUDD, T. N.
Book Reviews
Oxford University Press
1974-05-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/3/2/130-b
http://dx.doi.org/10.1093/ageing/3.2.130-b
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/1302015-05-19HighWireOUPageing:3:2
BOOK REVIEWS
RUDD, T. N.
Book Reviews
Oxford University Press
1974-05-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/3/2/130
http://dx.doi.org/10.1093/ageing/3.2.130
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/131-a2015-05-19HighWireOUPageing:3:2
BOOK REVIEWS
BRAVERMAN, A. M.
Book Reviews
Oxford University Press
1974-05-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/3/2/131-a
http://dx.doi.org/10.1093/ageing/3.2.131-a
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/1312015-05-19HighWireOUPageing:3:2
BOOK REVIEWS
LEEMING, J. T.
Book Reviews
Oxford University Press
1974-05-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/3/2/131
http://dx.doi.org/10.1093/ageing/3.2.131
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/692015-05-19HighWireOUPageing:3:2
ORIGINS OF THE BRITISH GERIATRICS SOCIETY
HOWELL, TREVOR
COMMENT
Oxford University Press
1974-05-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/3/2/69
http://dx.doi.org/10.1093/ageing/3.2.69
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/732015-05-19HighWireOUPageing:3:2
OSTEOMALACIA IN WELFARE INSTITUTIONS
CORLESS, D.
GUPTA, SHASHI PRABHA
Articles
It is suggested that residents in welfare institutions, as well as patients in long-stay hospitals, are at risk of developing osteomalacia.
Oxford University Press
1974-05-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/3/2/73
http://dx.doi.org/10.1093/ageing/3.2.73
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/762015-05-19HighWireOUPageing:3:2
CARDIAC AMYLOIDOSIS IN THE ELDERLY: ASSOCIATED ELEVATION OF SERUM ALKALINE PHOSPHATASE
HODKINSON, H. M.
POMERANCE, ARIELA
Articles
Cardiac amyloidosis in elderly patients is associated with elevation of serum alkaline phosphatase. This cannot be explained on the basis of co-existent hepatic amyloidosis and its pathogenesis remains obscure. The combination of raised alkaline phosphatase with cardiac failure of obscure cause in an elderly patient is a possible pointer to the diagnosis of cardiac amyloidosis.
Oxford University Press
1974-05-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/3/2/76
http://dx.doi.org/10.1093/ageing/3.2.76
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/792015-05-19HighWireOUPageing:3:2
DIGOXIN STUDIES IN THE ELDERLY
TAYLOR, B. B.
KENNEDY, R. D.
CAIRD, F. I.
Articles
Serum digoxin concentrations were measured by radio-immunoassay in seven elderly patients during digitalisation with digoxin 0.25 mg daily, without a loading dose. Serum concentrations in the therapeutic range (1–2 ng/ml) were reached in four days in five patients with normal renal function, while ‘toxic’ levels of 3 ng/ml were reached in the same time in two patients with renal impairment. Digoxin levels were measured after a single dose of 0.0625–0.25 mg in 16 digitalised patients, and the frequency of ventricular ectopic beats determined from continuous electrocardiographic records. Digoxin absorption was normal, peak serum levels, often over 3 ng/ml, being reached after 90 minutes. An increased frequency of ventricular ectopic beats was observed in three of four patients given digoxin 0.25 mg, but only three to four hours after peak serum levels.
Oxford University Press
1974-05-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/3/2/79
http://dx.doi.org/10.1093/ageing/3.2.79
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/852015-05-19HighWireOUPageing:3:2
THE EFFECT OF FRUSEMIDE AND ETHACRYNIC ACID ON CARBOHYDRATE METABOLISM
CONI, N. K.
GORDON, P. W. N.
MUKHERJEE, A. P.
READ, P. R.
Articles
A pilot study was carried out to compare the effect of ethacrynic acid and frusemide on glucose tolerance in ten elderly inpatients, who were suffering from hemiparesis. One subject had to be withdrawn. None was seriously ill, was previously known to be diabetic, or was taking a diuretic. The mean of two base-line glucose tolerance tests was compared with those after 14 days on one diuretic, after a further 11 days without a diuretic and after another 14 days period on the other diuretic. The values taken for comparison were the peak and two-hour sugar levels. No evidence emerged that either drug was inevitably diabetogenic in the short term, and indeed, if anything, they both appeared to possess slight anti-diabetic activity. The effect on carbohydrate metabolism is probably not a factor that needs to be taken into consideration when prescribing these drugs, but should hyperglycaemia develop during treatment, a change of diuretic is recommended. The glucose tolerance test was found to be more reproducible than anticipated, possibly due to the controlled circumstances. If the two-hour blood sugar is taken as the criterion, most elderly subjects showed evidence of impaired glucose tolerance.
Oxford University Press
1974-05-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/3/2/85
http://dx.doi.org/10.1093/ageing/3.2.85
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/912015-05-19HighWireOUPageing:3:2
SCORE CHANGES FOLLOWING REPEATED ADMINISTRATION OF MENTAL STATUS QUESTIONNAIRES
STONIER, P. D.
Articles
Two Mental Status Questionnaires (MSQ), administered only once each, failed to discriminate completely between mentally normal and demented patients. Retesting weekly for six consecutive weeks showed an improvement up to the normal level by those patients who were rated clinically normal but who did badly on the initial MSQ. On the other hand a group of patients clinically rated as demented, with similar initial scores to those low-scoring normal patients, improved much less. The relevance of these findings to the use of the MSQ in clinical trials and other situations is discussed.
Oxford University Press
1974-05-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/3/2/91
http://dx.doi.org/10.1093/ageing/3.2.91
en
Copyright (C) 1974, British Geriatrics Society
oai:open-archive.highwire.org:ageing:3/2/972015-05-19HighWireOUPageing:3:2
PLATELET FUNCTION IN ELDERLY SCORBUTICS
BANERJEE, A. K.
ETHERINGTON, M.
Articles
Platelet function tests were carried out on eight elderly patients with clinical and biochemical scurvy. These results are compared with the results of similar tests carried out on 14 normal elderly persons, 15 elderly persons with senile purpura and 27 young normal subjects. The findings and significance of these are discussed.
Oxford University Press
1974-05-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/3/2/97
http://dx.doi.org/10.1093/ageing/3.2.97
en
Copyright (C) 1974, British Geriatrics Society