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oai:open-archive.highwire.org:ageing:9/3/1372015-05-19HighWireOUPageing:9:3
ACUTE CONFUSIONAL STATES AND DEMENTIA IN THE ELDERLY: THE ROLE OF DEHYDRATION/VOLUME DEPLETION, PHYSICAL ILLNESS AND AGE
SEYMOUR, D. G.
HENSCHKE, P. J.
CAPE, R. D. T.
CAMPBELL, A. J.
Articles
A prospective study was undertaken to investigate the incidence and aetiology of acute confusional states in physically ill old people. The subjects were 71 patients aged 70 years or over who were admitted as emergencies to a general medical unit. Mental testing revealed that: (a) one in six patients had an acute confusional state on admission; and (b) one in four patients had evidence of dementia. The presence of dehydration/volume depletion at the time of admission was estimated by various parameters which were brought together to form a new index called the ‘dehydration score’. There was a definite statistical association between high degrees of dehydration/volume depletion and poor mental function. Advanced age, on the other hand, appeared to increase the risk of dehydration/volume depletion only slightly. It was also found that a patient's mental score was a much better guide to prognosis than age. The implications of these findings are discussed.
Oxford University Press
1980-08-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/9/3/137
http://dx.doi.org/10.1093/ageing/9.3.137
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/1472015-05-19HighWireOUPageing:9:3
ANEUPLOIDY IN CULTURED HUMAN LYMPHOCYTES: I. AGE AND SEX DIFFERENCES
MARTIN, JUDITH M.
KELLETT, J. M.
KAHN, J.
Articles
The chromosomes of the lymphocytes of 208 subjects have been analysed in order to determine the relationship between age, sex and aneuploidy. The subjects consisted of 111 females and 34 males all over 65 years and 31 females and 32 males aged between 18 and 32 years. The degree of hypodiploidy (chromosome loss) differs significantly between the elderly and young subjects of each sex and between the aged males and females. Hyperdiploidy differs significantly only between the old and the young females. Giemsa banding shows that, in elderly females, increased hypodiploidy is especially due to the loss of an X-chromosome. The possible mechanisms accounting for these results are discussed.
Oxford University Press
1980-08-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/9/3/147
http://dx.doi.org/10.1093/ageing/9.3.147
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/1542015-05-19HighWireOUPageing:9:3
AGED MEN AND ISCHAEMIC HEART DISEASE: SERUM CHOLESTEROL AND TRIGLYCERIDE LEVELS
HORSEY, JENNIFER
LIVESLEY, BRIAN
DICKERSON, J. W. T.
Articles
Fasting serum cholesterol and triglyceride levels, and lipoprotein electrophoretic patterns have been investigated in 42 men aged 67–92 years (mean 79 years). Although all the cholesterol and the majority of the triglyceride levels were within the normal range for younger people, both were significantly greater (<it>P</it>< 0.001 and <it>P</it><0.01 respectively) in old men who had a clinical history of ischaemic heart disease than in the aged controls, whereas, in patients with dysrhythmia-ischaemia the cholesterol levels were raised (<it>P</it> < 0.05) but not the triglycerides. An abnormality of lipoprotein profile was observed in 58% of patients with ischaemic heart disease; 7% of the controls; and 20% of patients having myocardial ischaemia associated with supraventricular dysrhythmia.
Oxford University Press
1980-08-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/9/3/154
http://dx.doi.org/10.1093/ageing/9.3.154
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/1572015-05-19HighWireOUPageing:9:3
MEASUREMENT OF EJECTION FRACTION IN THE ELDERLY
LATOUR, JUDITH
DE LA FUENTE, R.
CAIRD, F. I.
Articles
A simple, virtually non-invasive, radionuclide method of measurement of ejection fraction has been evaluated in a study of 60 elderly patients. The causes of difficulty are described. The mean difference between duplicate measurements is 4.9%. The range of values obtained corresponds well to that found by others, as does the relationship to systolic time intervals. The method should be of value particularly for the assessment of the effects of drugs on the myocardium.
Oxford University Press
1980-08-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/9/3/157
http://dx.doi.org/10.1093/ageing/9.3.157
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/1652015-05-19HighWireOUPageing:9:3
RENAL MANAGEMENT OF SODIUM UNDER INDOMETHACIN AND ALDOSTERONE IN THE ELDERLY
NÚÑEZ, J. F. MACÍAS
IGLESIAS, C. GARCÍA
ROMO, J. M. TABERNERO
COMMES, J. L. RODRÍGUEZ
BECERRA, L. CORBACHO
TOMERO, J. A. SANCHEZ
Articles
The tubular handling of sodium in two groups of healthy old people, under the action of indomethacin and aldosterone was studied. Urinary aldosterone elimination was measured. From the results obtained, it is deduced that the elderly lose sodium through incompetence of the distal nephron. The possibility is put forward of a Na-K-ATP <inf>ase</inf> deficit and/or interstitial fibrosis as being related to salt losses.
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/165
http://dx.doi.org/10.1093/ageing/9.3.165
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/1732015-05-19HighWireOUPageing:9:3
A SCHEME OF AUGMENTED HOME CARE FOR ACUTELY AND SUB-ACUTELY ILL ELDERLY PATIENTS: REPORT ON PILOT STUDY
CURRIE, C. T.
BURLEY, LINDSAY E.
DOULL, CHRISTINE
RAVETZ, CHRISTINE
SMITH, R. G.
WILLIAMSON, J.
Articles
A pilot study for a scheme of augmented home care for elderly patients with acute or sub-acute illnesses is described. General practitioner care was supplemented by the services of a geriatrician. Home Help and District Nursing Services were involved where appropriate. Functional recovery was assessed using a new index based on the individual patient's pre-morbid function. Of 37 patients treated at home, six required admission to hospital and three died. The remainder made satisfactory functional recovery. Preliminary evidence suggests that in patients with comparable illness, recovery of function in terms of the Activities of Daily Living is more rapid at home than in hospital. This augmented home-care scheme proved practicable and acceptable to patients and participants and suggests that further controlled studies should be carried out.
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/173
http://dx.doi.org/10.1093/ageing/9.3.173
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/1812015-05-19HighWireOUPageing:9:3
THE PREVENTION OF FALLS IN A GERIATRIC HOSPITAL
MORRIS, E. V.
ISAACS, BERNARD
Articles
All falls which occurred in a geriatric hospital in a period of one year were carefully recorded by nursing staff. Falls occurred most often in admission wards, less in rehabilitation wards and even less in long-stay wards. The incidence of falls was very much lower when patients were confined to bed as a result of industrial action by staff. Very few falls resulted in bone injury. The completion of accident reports by nurses after non-injurious falls is unproductive.
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/181
http://dx.doi.org/10.1093/ageing/9.3.181
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/1862015-05-19HighWireOUPageing:9:3
PHYSICAL TRAINING IN OLD MEN
ANIANSSON, AMELIE
GRIMBY, GUNNAR
RUNDGREN, ÅKE
SVANBORG, ALVAR
ÖRLANDER, JAN
Articles
In order to investigate to what extent physical training might influence age-related changes in muscle strength and muscle composition, 12 70-year-old men were trained for 45 minutes three times a week for 12 weeks with dynamic and static exercise. The subjects in the study were free of cardiovascular and locomotor symptoms. After training the aerobic capacity was increased and static and dynamic muscle strength at all measured angular velocities increased significantly. In the control group none of these changes was seen. The fibre composition showed a significantly higher proportion of Type II fibres after training. Enzymatic evidence of training adaptation was found with significant increments in enzymes as muscle myokinase and lactate dehydrogenase. The results have shown that aerobic capacity and muscle strength are trainable in 70-year-old men.
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/186
http://dx.doi.org/10.1093/ageing/9.3.186
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/1882015-05-19HighWireOUPageing:9:3
IS WEAKNESS IN OLD AGE DUE TO MUSCLE WASTING?
MACLENNAN, W. J.
HALL, M. R. P.
TIMOTHY, J. I.
ROBINSON, MAUREEN
Articles
Grip strength and fat-free mass (FFM) were measured in 158 men and 112 women of 65 years and over living at home. There was a striking decline in grip strength with increasing age in both men and women. A marginal decline in FFM was not statistically significant. Multiple regression analysis suggested that age had an effect on grip strength which was independent of FFM. An explanation for this pattern might be that with ageing an increasing proportion of skeletal muscle is replaced by fibrous tissue, so that, although there is striking reduction in muscle power, there is only a marginal reduction in FFM.
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/188
http://dx.doi.org/10.1093/ageing/9.3.188
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/1932015-05-19HighWireOUPageing:9:3
BRITISH SOCIETY FOR RESEARCH ON AGEING
Articles
The error theory of ageing is based on the premise that macromolecules are not synthesized with complete accuracy and that a proportion of faulty molecules will themselves.be responsible for further errors. If the feedback of errors is sufficiently high, then cells will inevitably accumulate lethal damage in either proteins or DNA. A number of experiments have been carried out to test the error theory and these will be reviewed. Most of the evidence for the theory from higher organisms is indirect, but in microbial systems it seems very likely that error propagation leading to cell death does occur under certain conditions. It is widely believed that observations have been made on proteins which are contrary to the predictions of the theory, but in fact the experimental procedures which have been used do not actually measure the error levels in young and old cells or tissues. For technical reasons, it is easier to measure changes in DNA than proteins and when this has been done an exponential increase in errors or mutations has been demonstrated during ageing.
Oxford University Press
1980-08-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/9/3/193
http://dx.doi.org/10.1093/ageing/9.3.193
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/197-a2015-05-19HighWireOUPageing:9:3
BOOK REVIEWS
INSLEY, MORAG L.
BOOK REVIEWS
Oxford University Press
1980-08-01 00:00:00.0
TEXT
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http://ageing.oxfordjournals.org/cgi/content/short/9/3/197-a
http://dx.doi.org/10.1093/ageing/9.3.197-a
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/197-b2015-05-19HighWireOUPageing:9:3
BOOK REVIEWS
MILLS, GORDON
BOOK REVIEWS
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/197-b
http://dx.doi.org/10.1093/ageing/9.3.197-b
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/1972015-05-19HighWireOUPageing:9:3
BOOK REVIEWS
INSLEY, MORAG L.
BOOK REVIEWS
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/197
http://dx.doi.org/10.1093/ageing/9.3.197
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/198-a2015-05-19HighWireOUPageing:9:3
BOOK REVIEWS
MILLER, R. G.
BOOK REVIEWS
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/198-a
http://dx.doi.org/10.1093/ageing/9.3.198-a
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/1982015-05-19HighWireOUPageing:9:3
BOOK REVIEWS
INSLEY, MORAG L.
BOOK REVIEWS
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/198
http://dx.doi.org/10.1093/ageing/9.3.198
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/1992015-05-19HighWireOUPageing:9:3
BOOK REVIEWS
BURSTON, G. R.
BOOK REVIEWS
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/199
http://dx.doi.org/10.1093/ageing/9.3.199
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/200-a2015-05-19HighWireOUPageing:9:3
BOOK REVIEWS
DAVISON, W.
BOOK REVIEWS
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/200-a
http://dx.doi.org/10.1093/ageing/9.3.200-a
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/2002015-05-19HighWireOUPageing:9:3
BOOK REVIEWS
NORTON, DOREEN
BOOK REVIEWS
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/200
http://dx.doi.org/10.1093/ageing/9.3.200
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/201-a2015-05-19HighWireOUPageing:9:3
BOOK REVIEWS
RUDD, T. N.
BOOK REVIEWS
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/201-a
http://dx.doi.org/10.1093/ageing/9.3.201-a
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/2012015-05-19HighWireOUPageing:9:3
BOOK REVIEWS
SHARLAND, D. E.
BOOK REVIEWS
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/201
http://dx.doi.org/10.1093/ageing/9.3.201
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/202-a2015-05-19HighWireOUPageing:9:3
BOOK REVIEWS
WRIGHT, W. B.
BOOK REVIEWS
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/202-a
http://dx.doi.org/10.1093/ageing/9.3.202-a
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/2022015-05-19HighWireOUPageing:9:3
BOOK REVIEWS
IRVINE, R. E.
BOOK REVIEWS
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/202
http://dx.doi.org/10.1093/ageing/9.3.202
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/203-a2015-05-19HighWireOUPageing:9:3
BOOKS RECEIVED
BOOKS RECEIVED
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/203-a
http://dx.doi.org/10.1093/ageing/9.3.203-a
en
Copyright (C) 1980, British Geriatrics Society
oai:open-archive.highwire.org:ageing:9/3/2032015-05-19HighWireOUPageing:9:3
BOOK REVIEWS
HELPS, E. P. W.
BOOK REVIEWS
Oxford University Press
1980-08-01 00:00:00.0
TEXT
text/html
http://ageing.oxfordjournals.org/cgi/content/short/9/3/203
http://dx.doi.org/10.1093/ageing/9.3.203
en
Copyright (C) 1980, British Geriatrics Society